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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1962 1
1963 2
1964 4
1965 5
1966 21
1967 50
1968 91
1969 111
1970 144
1971 161
1972 220
1973 219
1974 217
1975 216
1976 227
1977 221
1978 235
1979 247
1980 288
1981 306
1982 402
1983 419
1984 598
1985 841
1986 1010
1987 1274
1988 1473
1989 2035
1990 2373
1991 2555
1992 2952
1993 3233
1994 3475
1995 3785
1996 3806
1997 3997
1998 4170
1999 4334
2000 4678
2001 4886
2002 5241
2003 5758
2004 6434
2005 6961
2006 7795
2007 8647
2008 9188
2009 9987
2010 10805
2011 11677
2012 12550
2013 13502
2014 14170
2015 14779
2016 14846
2017 15328
2018 15964
2019 17382
2020 18513
2021 19344
2022 17382
2023 15959
2024 6106

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304,561 results

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Page 1
A gene regulatory network for cell fate specification in Ciona embryos.
Satou Y. Satou Y. Curr Top Dev Biol. 2020;139:1-33. doi: 10.1016/bs.ctdb.2020.01.001. Epub 2020 May 5. Curr Top Dev Biol. 2020. PMID: 32450958 Review.
These properties have provided an opportunity for examining the gene regulatory network at the single cell resolution and at a genome-wide scale. This article summarizes when and where each regulatory gene is expressed in early ascidian embryos, and th …
These properties have provided an opportunity for examining the gene regulatory network at the single cell resolution and at a …
Controlling gene expression timing through gene regulatory architecture.
Ali MZ, Brewster RC. Ali MZ, et al. PLoS Comput Biol. 2022 Jan 18;18(1):e1009745. doi: 10.1371/journal.pcbi.1009745. eCollection 2022 Jan. PLoS Comput Biol. 2022. PMID: 35041641 Free PMC article.
Gene networks typically involve the regulatory control of multiple genes with related function. This connectivity enables correlated control of the levels and timing of gene expression. Here we study how gene expression timing in the single-inpu
Gene networks typically involve the regulatory control of multiple genes with related function. This connectivity enabl
Regulatory gene mutation: a driving force behind group a Streptococcus strain- and serotype-specific variation.
Sarkar P, Sumby P. Sarkar P, et al. Mol Microbiol. 2017 Feb;103(4):576-589. doi: 10.1111/mmi.13584. Epub 2016 Dec 19. Mol Microbiol. 2017. PMID: 27868255 Free PMC article. Review.
Here, using the human bacterial pathogen the group A Streptococcus (GAS; S. pyogenes) as a model organism, we review the types and regulatory-, phenotypic-, and disease-specific consequences of naturally occurring regulatory gene mutations. ...We conclude tha …
Here, using the human bacterial pathogen the group A Streptococcus (GAS; S. pyogenes) as a model organism, we review the types and regula
Geometry of gene regulatory dynamics.
Rand DA, Raju A, Sáez M, Corson F, Siggia ED. Rand DA, et al. Proc Natl Acad Sci U S A. 2021 Sep 21;118(38):e2109729118. doi: 10.1073/pnas.2109729118. Proc Natl Acad Sci U S A. 2021. PMID: 34518231 Free PMC article.
The successive differentiation of different cell types that elaborate this complexity results from the activity of gene networks and was likened by Waddington to a flow through a landscape in which valleys represent alternative fates. ...Results from Smale and coworkers im …
The successive differentiation of different cell types that elaborate this complexity results from the activity of gene networks and …
The molecular and gene regulatory signature of a neuron.
Hobert O, Carrera I, Stefanakis N. Hobert O, et al. Trends Neurosci. 2010 Oct;33(10):435-45. doi: 10.1016/j.tins.2010.05.006. Trends Neurosci. 2010. PMID: 20663572 Free PMC article. Review.
Here, we discuss the composition of neuron-type specific gene batteries and illustrate gene regulatory strategies which determine the unique gene expression profiles and molecular composition of individual neuronal cell types from C. elegans to higher …
Here, we discuss the composition of neuron-type specific gene batteries and illustrate gene regulatory strategies which …
Gene regulatory networks.
Davidson E, Levin M. Davidson E, et al. Proc Natl Acad Sci U S A. 2005 Apr 5;102(14):4935. doi: 10.1073/pnas.0502024102. Epub 2005 Apr 4. Proc Natl Acad Sci U S A. 2005. PMID: 15809445 Free PMC article. No abstract available.
Regulatory gene function handoff allows essential gene loss in mosquitoes.
Cheatle Jarvela AM, Trelstad CS, Pick L. Cheatle Jarvela AM, et al. Commun Biol. 2020 Sep 30;3(1):540. doi: 10.1038/s42003-020-01203-w. Commun Biol. 2020. PMID: 32999445 Free PMC article.
It is difficult to understand how a regulatory gene could be lost from one species' genome when it is essential for viability in closely related species. ...Thus, paired was functionally replaced by the related gene, gooseberry, in mosquitoes. Our findings do …
It is difficult to understand how a regulatory gene could be lost from one species' genome when it is essential for viability …
Modeling the dynamics of transcriptional gene regulatory networks for animal development.
Ben-Tabou de-Leon S, Davidson EH. Ben-Tabou de-Leon S, et al. Dev Biol. 2009 Jan 15;325(2):317-28. doi: 10.1016/j.ydbio.2008.10.043. Epub 2008 Nov 12. Dev Biol. 2009. PMID: 19028486 Free PMC article. Review.
The dynamic process of cell fate specification is regulated by networks of regulatory genes. The architecture of the network defines the temporal order of specification events. ...We use this model to simulate gene expression, to distinguish between cis-re
The dynamic process of cell fate specification is regulated by networks of regulatory genes. The architecture of the network d …
Transcriptional regulation of gene expression in Corynebacterium glutamicum: the role of global, master and local regulators in the modular and hierarchical gene regulatory network.
Schröder J, Tauch A. Schröder J, et al. FEMS Microbiol Rev. 2010 Sep;34(5):685-737. doi: 10.1111/j.1574-6976.2010.00228.x. Epub 2010 Apr 14. FEMS Microbiol Rev. 2010. PMID: 20491930 Free article. Review.
Because of its industrial importance, C. glutamicum is one of the best-studied gram-positive bacteria and an emerging model for the suborder Corynebacterineae. Over the past years, the transcriptional regulation of gene expression was intensively studied in C. glutamicum t …
Because of its industrial importance, C. glutamicum is one of the best-studied gram-positive bacteria and an emerging model for the suborder …
Core transcriptional regulatory circuitry in human embryonic stem cells.
Boyer LA, Lee TI, Cole MF, Johnstone SE, Levine SS, Zucker JP, Guenther MG, Kumar RM, Murray HL, Jenner RG, Gifford DK, Melton DA, Jaenisch R, Young RA. Boyer LA, et al. Cell. 2005 Sep 23;122(6):947-56. doi: 10.1016/j.cell.2005.08.020. Cell. 2005. PMID: 16153702 Free PMC article.
To gain insights into transcriptional regulation of human ES cells, we have identified OCT4, SOX2, and NANOG target genes using genome-scale location analysis. We found, surprisingly, that OCT4, SOX2, and NANOG co-occupy a substantial portion of their target genes. …
To gain insights into transcriptional regulation of human ES cells, we have identified OCT4, SOX2, and NANOG target genes using genom …
304,561 results
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